What is TIPTOP?

The Transforming Intermittent Preventive Treatment for Optimal Pregnancy (TIPTOP) project is an innovative, community-based approach that aims to dramatically increase the number of pregnant women in malaria-affected countries in sub-Saharan Africa receiving antimalarial preventive therapy, thus saving the lives of thousands of mothers and newborns.

This 5-year landmark project will:

Health worker doing research

Generate Evidence

Generate evidence to inform change in policy recommendations across sub-Saharan Africa for the World Health Organization (WHO).

Pregnant mother with toddler

Increase coverage of IPTp

Introduce and set the stage for scale-up of community distribution of intermittent preventive treatment (IPTp) with quality assured (QA) sulfadoxine pyrimethamine (SP).

Hand receiving medication

Increase Demand

Introduce and increase demand for quality-assured (QA) SP.

Malaria in Pregnancy (MiP)

What is the danger of malaria in pregnancy?

Each year MiP is responsible for:

20% of stillbirths in sub-Saharan Africa

100,000 newborn deaths globally

10,000 maternal deaths globally

In malaria-endemic areas, 50 million women will become pregnant each year.

These women are highly susceptible to the consequences of malaria, which lead to:

Increased maternal death

Severe maternal anemia

Low birthweight

Infant death

IPTp-SP works

It provides significant benefit by reducing the incidence of:

Severe maternal anemia: 38%

Low birthweight: 29%

Infant death: 31%

Why is TIPTOP important?

Driving Impact

TIPTOP will drive impact in target countries and regionally to significantly increase coverage of pregnant women to prevent malaria in pregnancy.

Bending the Curve

TIPTOP will bend the curve—reaching the hardest to reach and drastically reducing missed opportunities for eligible pregnant women to receive SP.

Applying Innovation

TIPTOP will apply an innovative approach, complementary to antenatal care services: introducing community-level distribution of QA SP and driving market change with introduction of QA SP.

Health worker putting on gloves

Who is TIPTOP?

The five-year project, to be implemented and managed by Jhpiego, will increase IPTp coverage and expand antenatal care attendance in four African countries. Jhpiego has partnered with the Barcelona Institute for Global Health (ISGlobal), which will lead the research and evaluation components of the project. The two organizations will also collaborate with the World Health Organization (WHO) and Medicines for Malaria Venture to achieve the desired results.

Jhpiego—Johns Hopkins University Affiliate


Jhpiego, an international nonprofit health organization affiliated with the Johns Hopkins University, has worked for 45 years to empower frontline health workers by designing and implementing effective, low-cost, hands-on solutions to strengthen the delivery of health care services for women and their families. Jhpiego has been supporting MiP efforts in over 30 countries since 2001.



ISGlobal, the result of an innovative alliance between the “la Caixa” Foundation, academic institutions and government bodies, was set up to contribute to the work undertaken by the international community to address the challenges of health in a globalized world.



MMV is a leading product development partnership (PDP) in the field of antimalarial drug research and development with a mission of reducing the burden of malaria in disease-endemic countries by discovering, developing and facilitating delivery of new, effective and affordable antimalarial drugs.



WHO strives to build a better, healthier future for people all over the world and works side by side with governments and other partners to ensure the highest attainable level of health for all people. WHO supports countries to attain their health objectives and support their national health policies and strategies.

About our donor



Unitaid is an international organization that invests in new ways to prevent, diagnose and treat HIV/AIDS, hepatitis C, tuberculosis and malaria more quickly, more cheaply and more effectively. It accelerates access to innovation so critical health products reach the people who most need them. Unitaid’s work allows large-scale introduction of health products through funding by the Global Fund, the United States President’s Emergency Plan for AIDS Relief (PEPFAR) and governments.

Where is TIPTOP?

Hover over a country for additional information.

TIPTOP News and Announcements

What’s new in the TIPTOP project, including progress reports, photos, videos, updates, twitter feeds and stories from the field.

Pregnant mother illustration

Bending the curve: An innovative response to address malaria in pregnancy

TIPTOP celebrates World Malaria Day and is Ready to Beat Malaria! Find out how in this infographic.

Download Infographic
Mother and baby

TIPTOP project leaders discuss their work on Voice of America

TIPTOP was recently featured on the Health Chat segment of Voice of America. Health Chat is a live program that addresses health issues in Africa through discussions with guest health professionals. TIPTOP Project Director, Elaine Roman, and Senior Regional Technical and Programmatic Advisor, Dr. Emmanuel ‘Dipo Otolorin, fielded questions from Health Chat host Linord Moudou. During the segment, they discussed the burden of malaria in pregnancy, the importance of intermittent preventive treatment and the potential impact of the groundbreaking TIPTOP project.

Listen Here

TIPTOP Briefer

A summary of the TIPTOP project, including key objectives, partnership and country information, and the innovative approach to preventing MiP.

Download Briefer (English)

TIPTOP Announcement

Landmark Agreement Signed to Prevent Malaria in Pregnancy and Reduce Life-Threatening Complications in sub-Saharan Africa.

View Announcement

Contact TIPTOP

Subscribe to TIPTOPics

A quarterly newsletter from the TIPTOP project team

TIPTOP on Twitter

Join our twitter feed #tiptopmalaria


For general inquiries or specific requests, please contact: tiptopmalaria@jhpiego.org

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An innovative, community-based approach that aims to dramatically increase the number of pregnant women in malaria-affected countries in sub-Saharan Africa receiving life-saving antimalarial treatment.

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